Fig. 2

Schematic presentation of S. suis IgM protease molecule. Based on multi-sequence alignments the IgM protease can be divided into three main groups A, B and C. Within the IgM protease molecules 4 regions can be identified: Region 1 contains a MAC1 domain with predicted hydrolase activity. Region 2 is linked to structural function and has a sequence linked to substrate binding. Region 3 is a repeat region with predicted casein kinase II phosphorylation site (group A and C) or N-meristoylation site (group B). Region 4 is a trans-membrane region linked to cell wall anchoring. Same color indicates high level of amino acid identity